What causes ageing?

According to Professor David Sinclair, it is a loss of information in our epigenome, the system of proteins like histones and chemical markers like methylation that turn on and off genes.

Epigenetics allow different cell types to perform their specific functions – they are what differentiate a brain cell from a skin cell. Our DNA is constantly getting broken, by cosmic rays, UV radiation, free radicals, x-rays and regular cell division etc.

When our cells repair that damage, the epigenome is not perfectly reset. And hence over time, noise accumulates in our epigenome. Our cells no longer perform their functions well.

Could we actually reverse ageing?

New research suggests it is possible to slow or even reverse ageing. By changing the genes that are responsible for ageing, we may be able to ‘cure’ the ageing process in humans.

Currently, no such technology exists, however there is certainly a lot of promise for what the future may hold.

Supplementation of molecules such as NMN have been show to slow down the effects of ageing and even improve many health markers associated with longevity and vitality.

NAD+ is a key co-enzyme that the mitochondria in every cell of our bodies depend on to fuel all basic functions.

NAD+ play a key role in communicating between our cells nucleus and the Mitochondria that power all activity in our cells.

Scientists have now confirmed a direct link between falling NAD+ levels and aging in both animal and in human subjects.

As we age, our bodies produce less NAD+ and the communication between the Mitochondria and cell nucleus is impaired.

Over time, decreasing NAD+ impairs the cell’s ability to make energy, which leads to aging and disease and perhaps even the key factor in why we age.

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